Human TNFRSF13B/TACI ELISA Kit PicoKine® | Boster EK0986 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFRSF13B/TACI ELISA Kit PicoKine®

catalog :

EK0986

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0986

Product Name :

Human TNFRSF13B/TACI ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TNFRSF13B/TACI ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF13B in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF13B

Uniprot ID :

O14836

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S2-T166

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.7 pg/ml - 6,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 13B

Synonyms :

Tumor necrosis factor receptor superfamily member 13B;Transmembrane activator and CAML interactor;CD267;TNFRSF13B;TACI;

Protein Name :

Tumor necrosis factor receptor superfamily member 13B

Molecular Weight :

31816 MW

Protein Function :

Receptor for TNFSF13/APRIL and TNFSF13B/TALL1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-B and AP-1. Involved in the stimulation of B- and T- cell function and the regulation of humoral immunity.

Subcellular Localization :

Membrane; Single-pass type III membrane protein.

Tissue Specificity :

Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B- cells and activated T-cells, but not in resting T-cells.

Sequence Similarities :

Contains 2 TNFR-Cys repeats.

Background :

Tumor necrosis factor receptor superfamily member 13B, also known as TNFRSF13B or more commonly as TACI, is a transmembrane receptor protein found predominantly on the surface of B cells, which are an important part of the immune system. TACI controls T cell-independent B cell antibody responses, isotype switching, and B cell homeostasis. TACI is a lymphocyte-specific member of the tumor necrosis factor (TNF) receptor superfamily. It was originally discovered because of its ability to interact with calcium-modulator and cyclophilin ligand (CAML). TACI was later found to play a crucial role in humoral immunity by interacting with two members of the TNF family: BAFF and APRIL. These proteins signal through TACI inducing activation of several transcription factors including NFAT, AP-1, and NF-kappa-B which then modulate cellular activities. Defects in the function of TACI can lead to immune system diseases.