Human Periostin/OSF2 ELISA Kit PicoKine® | Boster EK0985 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Periostin/OSF2 ELISA Kit PicoKine®

catalog :

EK0985

quantity :

96 wells/kit, with removable strips.

price :

399 USD

more info or order :

Boster product webpage

citations: 1

Reference
Ben Q, Zhao Z, Ge S, Zhou J, Yuan F, Yuan Y. Circulating levels of periostin may help identify patients with more aggressive colorectal cancer. Int J Oncol. 2009;34:821-8 pubmed

image

image 1 :

Human Periostin/OSF2 PicoKine ELISA Kit standard curve

product information

SKU :

EK0985

Product Name :

Human Periostin/OSF2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

399 USD

Description :

Human Periostin/OSF2 ELISA Kit PicoKine® (96 Tests). Quantitate Human POSTN in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

POSTN

Uniprot ID :

Q15063

Immunogen :

Expression system for standard: NS0; Immunogen sequence: N22-Q836

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Periostin

Synonyms :

Periostin;PN;Osteoblast-specific factor 2;OSF-2;POSTN;OSF2;

Protein Name :

Periostin

Molecular Weight :

93314 MW

Protein Function :

Enhances incorporation of BMP1 in the fibronectin matrix of connective tissues, and subsequent proteolytic activation of lysyl oxidase LOX (By similarity). Induces cell attachment and spreading and plays a role in cell adhesion. May play a role in extracellular matrix mineralization.

Subcellular Localization :

Golgi apparatus . Secreted, extracellular space, extracellular matrix . Colocalizes with BMP1 in the Golgi.

Tissue Specificity :

Widely expressed with highest levels in aorta, stomach, lower gastrointestinal tract, placenta, uterus, thyroid tissue and breast. Up-regulated in epithelial ovarian tumors. Not expressed in normal ovaries. Also highly expressed at the tumor periphery of lung carcinoma tissue but not within the tumor. Overexpressed in breast cancers.

Sequence Similarities :

Contains 1 EMI domain.

Background :

Periostin, also known as OSF2, is a protein that in humans is encoded by the POSTN gene. The International Radiation Hybrid Mapping Consortium mapped the POSTN gene to chromosome 13. Periostin functions as a ligand for alpha-V/beta-3 and alpha-V/beta-5 integrins to support adhesion and migration of epithelial cells. It is found that periostin was overexpressed by the majority of human primary breast cancers examined. After myocardial infarction, periostin-induced cardiomyocyte cell cycle reentry and mitosis were associated with improved ventricular remodeling and myocardial function, reduced fibrosis and infarct size, and increase angiogenesis.

Research Category :

Atherosclerosis, Cancer, Cardiogenesis, Cardiovascular, Cell Adhesion Molecules, Cell Type Markers, Cytoskeleton / Ecm, Extracellular Matrix, Invasion/Microenvironment, Signal Transduction, Structures, Tags & Cell Markers, Vascular Inflammation

more info or order :

Boster product webpage