Human Progranulin ELISA Kit PicoKine® | Boster EK0973 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Progranulin ELISA Kit PicoKine®

catalog :

EK0973

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Yamamoto Y, Takemura M, Serrero G, Hayashi J, Yue B, Tsuboi A, et al. Increased serum GP88 (Progranulin) concentrations in rheumatoid arthritis. Inflammation. 2014;37:1806-13 pubmed publisher

product information

SKU :

EK0973

Product Name :

Human Progranulin ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human Progranulin ELISA Kit PicoKine® (96 Tests). Quantitate Human GRN in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

GRN

Uniprot ID :

P28799

Immunogen :

Expression system for standard: NS0; Immunogen sequence: T18-L593

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

1.56 ng/ml - 100 ng/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Granulins

Synonyms :

Granulins;Proepithelin;PEPI;Acrogranin;Glycoprotein of 88 Kda;GP88;Glycoprotein 88;Progranulin;Paragranulin;Granulin-1;Granulin G;Granulin-2;Granulin F;Granulin-3;Granulin B;Granulin-4;Granulin A;Granulin-5;Granulin C;Granulin-6;Granulin D;Granulin-7;Granulin E;GRN;

Protein Name :

Granulins

Molecular Weight :

63544 MW

Protein Function :

Granulins have possible cytokine-like activity. They may play a role in inflammation, wound repair, and tissue remodeling.

Subcellular Localization :

Secreted.

Tissue Specificity :

In myelogenous leukemic cell lines of promonocytic, promyelocytic, and proerythroid lineage, in fibroblasts, and very strongly in epithelial cell lines. Present in inflammatory cells and bone marrow. Highest levels in kidney.

Sequence Similarities :

Belongs to the granulin family.

Background :

Granulin, also known as Proepithelin (PEPI) is a protein that in humans is encoded by the GRN gene. This gene is mapped to 17q21.31. Granulins are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. The 88 kDa precursor protein, progranulin, is also called proepithelin and PC cell-derived growth factor. Cleavage of the signal peptide produces mature granulin which can be further cleaved into a variety of active, 6 kDa peptides. These smaller cleavage products are named granulin A, granulin B, granulin C, etc. Epithelins 1 and 2 are synonymous with granulins A and B, respectively. Both the peptides and intact granulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis.

Research Category :

Cancer, Immunology, Neurodegenerative Disease, Neurology Process, Neuroscience, Secreted Molecules, Signal Transduction

more info or order :

Boster product webpage