Human IL-28A ELISA Kit PicoKine® | Boster EK0969 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-28A ELISA Kit PicoKine®

catalog :

EK0969

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0969

Product Name :

Human IL-28A ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL-28A ELISA Kit PicoKine® (96 Tests). Quantitate Human IFNL2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IFNL2

Uniprot ID :

Q8IZJ0

Immunogen :

Expression system for standard: NS0; Immunogen sequence: V26-V200

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interferon lambda-2

Synonyms :

Interferon lambda-2;IFN-lambda-2;Cytokine Zcyto20;Interleukin-28A;IL-28A;IFNL2;IL28A, ZCYTO20;

Protein Name :

Interferon lambda-2

Molecular Weight :

22288 MW

Protein Function :

Cytokine with antiviral, antitumour and immunomodulatory activities. Plays a critical role in the antiviral host defense, predominantly in the epithelial tissues. Acts as a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IFNLR1, and receptor engagement leads to the activation of the JAK/STAT signaling pathway resulting in the expression of IFN- stimulated genes (ISG), which mediate the antiviral state. Has a restricted receptor distribution and therefore restricted targets: is primarily active in epithelial cells and this cell type- selective action is because of the epithelial cell-specific expression of its receptor IFNLR1. Seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. Plays a significant role in the antiviral immune defense in the intestinal epithelium. Exerts an immunomodulatory effect by up-regulating MHC class I antigen expression.

Subcellular Localization :

Secreted .

Sequence Similarities :

Belongs to the lambda interferon family.

Background :

Interferon lambda-2, also called IFNL2 or IL28A is a class II cytokine receptor ligand related to type I interferons. This gene is mapped to 19q13.2. This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine genes that form a cytokine gene cluster. It up-regulates MHC class I antigen expression. It also displays antitumor activity. The ligand/receptor complex seems to signal through the Jak-STAT pathway. This gene seems not to be essential for early virus-activated host defense in vaginal infection, but plays an important role in Toll-like receptor (TLR)-induced antiviral defense. It seems play a significant role in the antiviral immune defense in the intestinal epithelium.

Research Category :

Immunology, Microbiology, Host Virus Interaction, Interspecies Interaction, Innate Immunity, Cytokines, Interferons, Interleukins