Human Sclerostin/SOST ELISA Kit PicoKine® | Boster EK0968 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Sclerostin/SOST ELISA Kit PicoKine®

catalog :

EK0968

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0968

Product Name :

Human Sclerostin/SOST ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Sclerostin/SOST ELISA Kit PicoKine® (96 Tests). Quantitate Human SOST in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SOST

Uniprot ID :

Q9BQB4

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q24-Y213

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Sclerostin

Synonyms :

Sclerostin;SOST;UNQ2976/PRO7455/PRO7476;

Protein Name :

Sclerostin

Molecular Weight :

24031 MW

Protein Function :

Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix .

Tissue Specificity :

Widely expressed at low levels with highest levels in bone, cartilage, kidney, liver, bone marrow and primary osteoblasts differentiated for 21 days. Detected in the subendothelial layer of the aortic intima (at protein level).

Background :

Sclerostin is a protein that in humans is encoded by the SOST gene. It is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Additionally, Sclerostin is produced by the osteocyte and has anti-anabolic effects on bone formation. The SOST gene maps to chromosome 17q12-q21.

Research Category :

Cytoskeleton / Ecm, Developmental Biology, Extracellular Matrix, Growth Factors/Hormones, Metabolism, Organogenesis, Secreted, Signal Transduction, Signaling Pathways, Skeletal Development, Stem Cells, Structures