Human LYVE-1 ELISA Kit PicoKine® | Boster EK0967 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human LYVE-1 ELISA Kit PicoKine®

catalog :

EK0967

quantity :

96 wells/kit, with removable strips.

price :

399 USD

more info or order :

Boster product webpage

citations: 1

Reference
Nunomiya K, Shibata Y, Abe S, Inoue S, Igarashi A, Yamauchi K, et al. Relationship between Serum Level of Lymphatic Vessel Endothelial Hyaluronan Receptor-1 and Prognosis in Patients with Lung Cancer. J Cancer. 2014;5:242-7 pubmed publisher

image

image 1 :

Human LYVE-1 PicoKine ELISA Kit standard curve

product information

SKU :

EK0967

Product Name :

Human LYVE-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

399 USD

Description :

Human LYVE-1 ELISA Kit PicoKine® (96 Tests). Quantitate Human LYVE1 in cell culture supernatants and cell lysates. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

LYVE1

Uniprot ID :

Q9Y5Y7

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S24-T238

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and cell lysate

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Lymphatic vessel endothelial hyaluronic acid receptor 1

Synonyms :

Lymphatic vessel endothelial hyaluronic acid receptor 1;LYVE-1;Cell surface retention sequence-binding protein 1;CRSBP-1;Extracellular link domain-containing protein 1;Hyaluronic acid receptor;LYVE1;CRSBP1, HAR, XLKD1;UNQ230/PRO263;

Protein Name :

Lymphatic vessel endothelial hyaluronic acid receptor 1

Molecular Weight :

35213 MW

Protein Function :

Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Subcellular Localization :

Membrane ; Single-pass type I membrane protein . Localized to the plasma membrane and in vesicles near extranuclear membranes which may represent trans-Golgi network (TGN) and endosomes/prelysosomeal compartments. Undergoes ligand- dependent internalization and recycling at the cell surface.

Tissue Specificity :

Mainly expressed in endothelial cells lining lymphatic vessels.

Background :

Extracellular link domain containing 1, also known as LYVE-1 or XLKD1 is a human gene. The International Radiation Hybrid Mapping Consortium mapped the LYVE1 gene to chromosome 11p15.4. This gene encodes a type I integral membrane glycoprotein. The encoded protein acts as a receptor and binds to both soluble and immobilized hyaluronan. This protein may function in lymphatic hyaluronan transport and have a role in tumor metastasis. This gene may play a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). It may act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes.

Research Category :

Cardiovascular, Vasculature

more info or order :

Boster product webpage