Human MICB ELISA Kit PicoKine® | Boster EK0963 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human MICB ELISA Kit PicoKine®

catalog :

EK0963

quantity :

96 wells/kit, with removable strips.

price :

399 USD

more info or order :

Boster product webpage

citations: 1

Reference
Holdenrieder S, Eichhorn P, Beuers U, Samtleben W, Stieber P, Nagel D, et al. Soluble NKG2D ligands in hepatic autoimmune diseases and in benign diseases involved in marker metabolism. Anticancer Res. 2007;27:2041-5 pubmed

image

image 1 :

Human MICB PicoKine ELISA Kit standard curve

product information

SKU :

EK0963

Product Name :

Human MICB ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

399 USD

Description :

Human MICB ELISA Kit PicoKine® (96 Tests). Quantitate Human MICB in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

MICB

Uniprot ID :

Q29980

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A23-G298

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

MHC class I polypeptide-related sequence B

Synonyms :

MHC class I polypeptide-related sequence B;MIC-B;MICB ;PERB11.2 ;

Protein Name :

MHC class I polypeptide-related sequence B

Molecular Weight :

42646 MW

Protein Function :

Seems to have no role in antigen presentation. Acts as a stress-induced self-antigen that is recognized by gamma delta T cells. Ligand for the KLRK1/NKG2D receptor. Binding to KLRK1 leads to cell lysis.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein . Binding to human cytomegalovirus glycoprotein UL16 causes sequestration in the endoplasmic reticulum.

Tissue Specificity :

Widely expressed with the exception of the central nervous system where it is absent. Expressed in many, but not all, epithelial tumors of lung, breast, kidney, ovary, prostate and colon. In hepatocellular carcinomas, expressed in tumor cells but not in surrounding non-cancerous tissue.

Sequence Similarities :

Belongs to the MHC class I family. MIC subfamily.

Background :

MHC class I polypeptide-related sequence B, also called MICB is a protein that in humans is encoded by the MICB gene. The MICB gene is mapped to 6p21.33. This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides. It seems to have no role in antigen presentation. This gene acts as a stress-induced self-antigen that is recognized by gamma delta T cells. It is the ligand for the KLRK1/NKG2D receptor and binds to KLRK1 leads to cell lysis.

Research Category :

Adaptive Immunity, Class I, Immunology

more info or order :

Boster product webpage