Human PD-1 ELISA Kit PicoKine® | Boster EK0959 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PD-1 ELISA Kit PicoKine®

catalog :

EK0959

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0959

Product Name :

Human PD-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PD-1 ELISA Kit PicoKine® (96 Tests). Quantitate Human PDCD1 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PDCD1

Uniprot ID :

Q15116

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L25-Q167

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Programmed cell death protein 1

Synonyms :

Programmed cell death protein 1;Protein PD-1;hPD-1;CD279;PDCD1;PD1;

Protein Name :

Programmed cell death protein 1

Molecular Weight :

31647 MW

Protein Function :

Inhibitory cell surface receptor involved in the regulation of T-cell function during immunity and tolerance. Upon ligand binding, inhibits T-cell effector functions in an antigen- specific manner. Possible cell death inducer, in association with other factors.

Subcellular Localization :

Membrane; Single-pass type I membrane protein.

Background :

Programmed cell death protein 1, also called PD-1 or PDCD1 is a protein that in humans is encoded by the PDCD1 gene. This gene encodes a cell surface membrane protein of the immunoglobulin superfamily. By fluorescence in situ hybridization, the PDCD1 gene is mapped to 2q37.3. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.

Research Category :

Apoptosis, Associated Proteins, Cell Biology, Developmental Biology, Intracellular, Neurogenesis, Neurology Process, Neuroscience, Organogenesis, Protein Phosphorylation, Ser / Thr Kinases, Signal Transduction