Human PDGF-BB ELISA Kit PicoKine® | Boster EK0956 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PDGF-BB ELISA Kit PicoKine®

catalog :

EK0956

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0956

Product Name :

Human PDGF-BB ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PDGF-BB ELISA Kit PicoKine® (96 Tests). Quantitate Human PDGFB in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml .

Reactivity :

Human

Application :

ELISA

Gene Name :

PDGFB

Uniprot ID :

P01127

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S82-T190

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Platelet-derived growth factor subunit B

Synonyms :

Platelet-derived growth factor subunit B; PDGF subunit B; PDGF-2; Platelet-derived growth factor B chain; Platelet-derived growth factor beta polypeptide; Proto-oncogene c-Sis; INN: Becaplermin; PDGFB; PDGF2; SIS

Protein Function :

Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin (PubMed:26599395). Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA (By similarity).

Tissue Specificity :

Expressed at high levels in the heart, brain (sustantia nigra), placenta and fetal kidney. Expressed at moderate levels in the brain (hippocampus), skeletal muscle, kidney and lung.

Sequence Similarities :

Belongs to the PDGF/VEGF growth factor family.

Background :

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this gene is a member of the platelet-derived growth factor family. This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. This gene is mapped to 22q13.1. Growth factor plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. This gene plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA.

Research Category :

Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Growth Factors, Growth Factors/Hormones, Immunology, Metabolism, Metabolism Processes, Neurology Process, Neuroscience, Pathways And Processes, Platelets, Response To Hypoxia, Secreted Molecules, Serum Proteins, Signal Transduction, Vascular Inflammation