Mouse TIMP-2 ELISA Kit PicoKine® | Boster EK0955 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TIMP-2 ELISA Kit PicoKine®

catalog :

EK0955

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0955

Product Name :

Mouse TIMP-2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TIMP-2 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Timp2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TIMP2

Uniprot ID :

P25785

Immunogen :

Expression system for standard: NS0; Immunogen sequence: C27-P220

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Metalloproteinase inhibitor 2

Synonyms :

Metalloproteinase inhibitor 2;Tissue inhibitor of metalloproteinases 2;TIMP-2;Timp2;Timp-2;

Protein Name :

Metalloproteinase inhibitor 2

Molecular Weight :

24328 MW

Protein Function :

Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor.

Subcellular Localization :

Secreted.

Tissue Specificity :

Detected in testis, retina, hippocampus and cerebral cortex.

Sequence Similarities :

Belongs to the protease inhibitor I35 (TIMP) family.

Background :

TIMP-2 gen is encoded by 5 exons spanning 83 kb of genomic DNA. TIMP-2 is 83 kilobase pairs (kb) long with exon-intron splicing sites located in preserved positions among the three members of the TIMP family. The gene for tissue inhibitor of metalloproteinases-2 is localized on human chromosome arm 17q25. TIMP-2 abrogates angiogenic factor-induced endothelial cell proliferation in vitro and angiogenesis in vivo independent of MMP inhibition. The standard product used in this kit is recombinant human TIMP-2 with the molecular mass of 22Kda and 194 amino acid.

Research Category :

Angiogenesis, Atherosclerosis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Protease Inhibitors, Proteolysis / Ubiquitin, Signal Transduction