Mouse Endothelin 1/EDN1 ELISA Kit PicoKine® | Boster EK0953 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Endothelin 1/EDN1 ELISA Kit PicoKine®

catalog :

EK0953

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0953

Product Name :

Mouse Endothelin 1/EDN1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse Endothelin 1/EDN1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Edn1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 0.5pg/ml.

Reactivity :

Mouse

Predicted Reactivity :

Hamster

Application :

ELISA

Gene Name :

EDN1

Uniprot ID :

P22387

Immunogen :

Expression system for standard: human peptide; Immunogen sequence: C53-W73

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

3.9 pg/ml - 250 pg/ml

Sensitivity :

<0.5 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, monoclonal antibody from mouse

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Endothelin-1

Synonyms :

Endothelin-1;ET-1;Preproendothelin-1;PPET1;Edn1;

Protein Name :

Endothelin-1

Molecular Weight :

22809 MW

Protein Function :

Endothelins are endothelium-derived vasoconstrictor peptides.

Subcellular Localization :

Secreted.

Tissue Specificity :

Highest expression in the adult is in lung. Lower levels found in heart, kidney, brain and intestine. In the embryo, expressed in outer and inner pharyngeal arch surfaces. Also expressed in endothelium of dorsal aorta and arch arteries, and in epithelium of pharyngeal pouches.

Background :

The endothelins is a family of structurally and pharmacologically distinct peptides, which has been identified and sequenced in humans. Three isoforms of human endothelin have been identified: endothelin-1, -2, and -3. Endothelin-1 is a potent, 21-amino acid vasoconstrictor peptide produced by vascular endothelial cells. Endothelins are 21-amino acid vasoconstricting peptides produced primarily in the endothelium having a key role in vascular homeostasis. Endothelins are implicated in vascular diseases of several organ systems, including the heart, general circulation and brain. Endothelins are proteins that constrict blood vessels and raise blood pressure. They are normally kept in balance by other mechanisms, but when they are over-expressed, they contribute to high blood pressure (hypertension) and heart disease.

Research Category :

Cancer, Cancer Metabolism, Cardiovascular, Growth Factors/Hormones, Metabolism, Metabolism Processes, Pathways And Processes, Response To Hypoxia, Signal Transduction, Vasculature