Rat CCL4/MIP-1 Beta ELISA Kit PicoKine® | Boster EK0939 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Rat CCL4/MIP-1 Beta ELISA Kit PicoKine®

catalog :

EK0939

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0939

Product Name :

Rat CCL4/MIP-1 Beta ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Rat CCL4/MIP-1 Beta ELISA Kit PicoKine® (96 Tests). Quantitate Rat Ccl4 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 10pg/ml.

Reactivity :

Rat

Application :

ELISA

Gene Name :

CCL4

Uniprot ID :

P50230

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: A24-N92

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-C motif chemokine 4

Synonyms :

C-C motif chemokine 4;Macrophage inflammatory protein 1-beta;MIP-1-beta;Small-inducible cytokine A4;Ccl4;Mip1b, Scya4;

Protein Name :

C-C motif chemokine 4

Molecular Weight :

10234 MW

Protein Function :

Monokine with inflammatory and chemokinetic properties.

Subcellular Localization :

Secreted.

Background :

Chemokine (C-C motif) ligand 4, also known as CCL4, is a protein which in mouse is encoded by the CCL4 gene. It is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. Performing-low memory CD8+ T cells that normally synthesize MIP-1-beta. By analysis of somatic cell hybrids and by in situ hybridization, the CCL4 gene was assigned to 17q21-q23. Based on functional analysis of MIP-1beta, one or more additional beta chemokine receptors that transduce MIP-1beta signals must also exist. MIP-1alpha and MIP-1beta have been shown to lack affinity for the erythrocyte surface chemokine receptor/Duffy antigen that binds many alpha as well as beta chemokines (11, 14).

Research Category :

Antiviral Signaling, Chemokines, Immune System Diseases, Immunology, Innate Immunity, Macrophage / Inflamm.