Mouse Angiopoietin-2 ELISA Kit PicoKine® | Boster EK0938 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Angiopoietin-2 ELISA Kit PicoKine®

catalog :

EK0938

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0938

Product Name :

Mouse Angiopoietin-2 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse Angiopoietin-2 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Angpt2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

ANGPT2

Uniprot ID :

O35608

Immunogen :

Expression system for standard: CHO; Immunogen sequence: M1-F496

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Angiopoietin-2

Synonyms :

Angiopoietin-2;ANG-2;Angpt2;Agpt2;

Protein Name :

Angiopoietin 2

Molecular Weight :

56576 MW

Protein Function :

Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal (By similarity).

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed only at sites of vascular remodeling.

Background :

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular endothelium. ANGPT2 is a naturally occurring antagonist of angiopoietin-1 that competes for binding to the TIE2 receptor and blocks ANGPT1-induced TIE2 autophosphorylation during vasculogenesis. Its expression occurs at sites of vascular remodelling: dorsal aorta and major aortic branches, ovary, placenta and uterus.

Research Category :

Angiogenesis, Cardiovascular, Growth Factors