ELISA/assay

Human ADAM12 / MCMP ELISA Kit PicoKine®

EK0934

96 wells/kit, with removable strips.

369 USD

Human ADAM12 / MCMP ELISA Kit PicoKine®

96 wells/kit, with removable strips.

369 USD

Human ADAM12 / MCMP ELISA Kit PicoKine® (96 Tests). Quantitate Human ADAM12 in cell culture supernatants, serum, plasma (heparin) and urine. Sensitivity: 10pg/ml.

Human

ELISA

ADAM12

O43184

Expression system for standard: CHO; Immunogen sequence: R29-S513

There is no detectable cross-reactivity with other relevant proteins.

156 pg/ml - 10,000 pg/ml

<10 pg/ml

cell culture supernatants, serum, plasma (heparin) and urine

monoclonal antibody from mouse, polyclonal antibody from goat

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Disintegrin and metalloproteinase domain-containing protein 12

Disintegrin and metalloproteinase domain-containing protein 12;ADAM 12;3.4.24.-;Meltrin-alpha;ADAM12;MLTN;UNQ346/PRO545;

Disintegrin and metalloproteinase domain-containing protein 12

99542 MW

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity).

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas.

Contains 1 disintegrin domain.

ADAM12 (Disintegrin and metalloproteinase domain-containing protein 12), also known as MLTN, is an enzyme that in humans is encoded by the ADAM12 gene. This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene has two alternatively spliced transcripts: a shorter secreted form and a longer membrane-bound form. The shorter form is found to stimulate myogenesis. By RT-PCR and immunoblot analyses that expression of mouse Adam12 increases during muscle regeneration, while the levels of other ADAMs remain constant. Immunofluorescence analysis revealed staining of small, newly formed muscle fibers in regenerating but not normal adult muscle cells. By using of fluorescence in situ hybridization, the ADAM12 gene is mapped to human chromosome 10q26.3.

Cancer, Cell Adhesion, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Integrins, Invasion/Microenvironment, Metalloprotease, Proteolysis / Ubiquitin, Proteolytic Enzymes, Signal Transduction