Mouse IL-33 ELISA Kit PicoKine® | Boster EK0930 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse IL-33 ELISA Kit PicoKine®

catalog :

EK0930

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0930

Product Name :

Mouse IL-33 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse IL-33 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Il33 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

IL33

Uniprot ID :

Q8BVZ5

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S109-I266

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-33

Synonyms :

Interleukin-33;IL-33;Interleukin-33 (102-266);Interleukin-33 (109-266);Il33;

Protein Name :

Interleukin-33

Molecular Weight :

29991 MW

Protein Function :

Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.

Subcellular Localization :

Nucleus. Chromosome. Cytoplasmic vesicle, secretory vesicle . Secreted. Associates with heterochromatin and mitotic chromosomes. Translocation from the nucleus occurs upon biomechanical strain, depends on an intact microtubule network, and is ATP-dependent (By similarity).

Background :

Interleukin 33 (IL-33) is a cytokine belonging to the IL-1 superfamily. By genomic sequence analysis, the IL33 gene is mapped to chromosome 9p24.1 and its mouse homolog to a syntenic region on chromosome 19qC1. The induction of type 2 cytokines by IL-33 in vivo is believed to induce the severe pathological changes observed in mucosal organs following administration of IL-33. IL33, an alarmin released from necrotic cells, is necessary for potent CD8 + T cell (CTL) responses to replicating, prototypic RNA, and DNA viruses in mice. IL33 prevented the downregulation of CXCR2 and inhibition of chemotaxis induced by activation of TLR4, and found that IL33 reverses the TLR4-induced reduction of CXCR2 expression via the inhibition of expression of GRK2.

Research Category :

Angiogenesis, Cardiovascular, Cytokines, Hypertrophy, Immunology, Innate Immunity, Interleukins