Human ADAMTS13 ELISA Kit PicoKine® | Boster EK0927 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human ADAMTS13 ELISA Kit PicoKine®

catalog :

EK0927

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0927

Product Name :

Human ADAMTS13 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human ADAMTS13 ELISA Kit PicoKine® (96 Tests). Quantitate Human ADAMTS13 in cell culture supernatants, serum and plasma (heparin, EDTA, citrate). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ADAMTS13

Uniprot ID :

Q76LX8

Immunogen :

Expression system for standard: CHO; Immunogen sequence: Q34-W688

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

0.78 ng/ml - 50 ng/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA, citrate)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

A disintegrin and metalloproteinase with thrombospondin motifs 13

Synonyms :

A disintegrin and metalloproteinase with thrombospondin motifs 13;ADAM-TS 13;ADAM-TS13;ADAMTS-13;3.4.24.87;von Willebrand factor-cleaving protease;vWF-CP;vWF-cleaving protease;ADAMTS13;C9orf8;UNQ6102/PRO20085;

Protein Name :

A disintegrin and metalloproteinase with thrombospondin motifs 13

Molecular Weight :

153604 MW

Protein Function :

Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.

Subcellular Localization :

Secreted . Secretion enhanced by O-fucosylation of TSP type-1 repeats.

Tissue Specificity :

Plasma. Expressed primarily in liver.

Background :

ADAMTS13 is a zinc-containing metalloprotease enzyme. The ADAMTS13 gene is mapped to chromosome 9q34 by genomic sequence analysis. It is reported that a metal-containing proteolytic enzyme (metalloprotease) in normal plasma cleaves the peptide bond between tyrosine at position 842 and methionine at position 843 in monomeric subunits of von Willebrand factor, thereby degrading the large multimers. And it is confirmed that the ADAMTS13 gene encodes the von Willebrand factor-cleaving protease (VWFCP). ADAMTS13 is secreted in blood and degrades large vWf multimers, decreasing their activity.

Research Category :

Cancer, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis / Ubiquitin, Proteolytic Enzymes, Signal Transduction