Human CD244/2B4 ELISA Kit PicoKine® | Boster EK0926 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CD244/2B4 ELISA Kit PicoKine®

catalog :

EK0926

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0926

Product Name :

Human CD244/2B4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CD244/2B4 ELISA Kit PicoKine® (96 Tests). Quantitate Human CD244 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CD244

Uniprot ID :

Q9BZW8

Immunogen :

Expression system for standard: NS0; Immunogen sequence: C22-R221

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Natural killer cell receptor 2B4

Synonyms :

Natural killer cell receptor 2B4;NK cell activation-inducing ligand;NAIL;NK cell type I receptor protein 2B4;NKR2B4;h2B4;SLAM family member 4;SLAMF4;Signaling lymphocytic activation molecule 4;CD244;CD244;2B4;

Protein Name :

Natural killer cell receptor 2B4

Molecular Weight :

41616 MW

Protein Function :

Modulate other receptor-ligand interactions to enhance leukocyte activation. CD244/2B4 is the only heterophilic receptor of SLAM family.

Subcellular Localization :

Membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Expressed in spleen, PBL, followed by lung, liver, testis and small intestine. Expressed not only in NK cells, but also on monocytes and basophils.

Background :

CD244 (Cluster of Differentiation 244) is a human protein encoded by the CD244 gene. It is also known as Natural Killer Cell Receptor 2B4. Members of the CD2 family adhere to each other instead,the cell surface glycoprotein 2B4 is related to CD2 and is implicated in the regulation of NK- and T-cell function. The 2B4 gene was mapped to 1q22 on gene map, where SLAM, CD48, CD84 and LY9 are also located. Using recombinant human NK cell-activating ligand 2B4 fused to domains 3 and 4 of rodent Cd4 and flow cytometric analysis, It was found that CD48 binds to 2B4. BIAcore surface plasmon resonance analysis showed that the affinity of CD48 for 2B4 is approximately 10-fold higher than that shown for CD48 and CD2.

Research Category :

Cell Type Markers, Hematopoietic Progenitors, Immunology, Lymphoid, Nk Cells, Stem Cells, T Lymphocytic Lineage