Human TNFSF12/Tweak ELISA Kit PicoKine® | Boster EK0920 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TNFSF12/Tweak ELISA Kit PicoKine®

catalog :

EK0920

quantity :

96 wells/kit, with removable strips.

price :

369 USD

more info or order :

Boster product webpage

citations: 1

Reference
Kowal Bielecka O, Bielecki M, Guiducci S, Trzcińska Butkiewicz B, Michalska Jakubus M, Matucci Cerinic M, et al. High serum sCD163/sTWEAK ratio is associated with lower risk of digital ulcers but more severe skin disease in patients with systemic sclerosis. Arthritis Res Ther. 2013;15:R69 pubmed

image

image 1 :

Human TNFSF12 PicoKine ELISA Kit standard curve

product information

SKU :

EK0920

Product Name :

Human TNFSF12/Tweak ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

369 USD

Description :

Human TNFSF12/Tweak ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFSF12 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFSF12

Uniprot ID :

O43508

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: S94-H249

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor ligand superfamily member 12

Synonyms :

Tumor necrosis factor ligand superfamily member 12;APO3 ligand;TNF-related weak inducer of apoptosis;TWEAK;Tumor necrosis factor ligand superfamily member 12, membrane form;Tumor necrosis factor ligand superfamily member 12, secreted form;TNFSF12;APO3L, DR3LG;UNQ181/PRO207;

Protein Name :

Tumor necrosis factor ligand superfamily member 12

Molecular Weight :

27216 MW

Protein Function :

Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion.

Subcellular Localization :

Cell membrane ; Single-pass type II membrane protein .

Tissue Specificity :

Highly expressed in adult heart, pancreas, skeletal muscle, brain, colon, small intestine, lung, ovary, prostate, spleen, lymph node, appendix and peripheral blood lymphocytes. Low expression in kidney, testis, liver, placenta, thymus and bone marrow. Also detected in fetal kidney, liver, lung and brain.

Sequence Similarities :

Belongs to the tumor necrosis factor family.

Background :

Tumor necrosis factor ligand superfamily member 12 also known as TNF-related weak inducer of apoptosis (TWEAK) is a protein that in humans is encoded by the TNFSF12 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is a ligand for the FN14/TWEAKR receptor. This cytokine has overlapping signaling functions with TNF, but displays a much wider tissue distribution. This cytokine can induce apoptosis via multiple pathways of cell death in a cell type-specific manner. This cytokine is also found to promote proliferation and migration of endothelial cells, and thus acts as a regulator ofangiogenesis. The TNFSF12 gene lies 878 bp upstream of the putative transcriptional start site of the TNFSF13 gene on chromosome 17p13.1.

Research Category :

Apoptosis, Cancer, Cell Biology, Cell Death, Growth Factors, Invasion/Microenvironment

more info or order :

Boster product webpage