Human COMP/Thrombospondin 5 ELISA Kit PicoKine® | Boster EK0913 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human COMP/Thrombospondin 5 ELISA Kit PicoKine®

catalog :

EK0913

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0913

Product Name :

Human COMP/Thrombospondin 5 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human COMP/Thrombospondin 5 ELISA Kit PicoKine® (96 Tests). Quantitate Human COMP in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

COMP

Uniprot ID :

P49747

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q21-A757

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cartilage oligomeric matrix protein

Synonyms :

Cartilage oligomeric matrix protein;COMP;Thrombospondin-5;TSP5;COMP;

Protein Name :

Cartilage oligomeric matrix protein

Molecular Weight :

82860 MW

Protein Function :

May play a role in the structural integrity of cartilage via its interaction with other extracellular matrix proteins such as the collagens and fibronectin. Can mediate the interaction of chondrocytes with the cartilage extracellular matrix through interaction with cell surface integrin receptors. Could play a role in the pathogenesis of osteoarthritis. Potent suppressor of apoptosis in both primary chondrocytes and transformed cells. Suppresses apoptosis by blocking the activation of caspase-3 and by inducing the IAP family of survival proteins (BIRC3, BIRC2, BIRC5 and XIAP). Essential for maintaining a vascular smooth muscle cells (VSMCs) contractile/differentiated phenotype under physiological and pathological stimuli. Maintains this phenotype of VSMCs by interacting with ITGA7 (By similarity).

Subcellular Localization :

Secreted, extracellular space, extracellular matrix.

Tissue Specificity :

Abundantly expressed in the chondrocyte extracellular matrix, and is also found in bone, tendon, ligament and synovium and blood vessels. Increased amounts are produced during late stages of osteoarthritis in the area adjacent to the main defect.

Sequence Similarities :

Belongs to the thrombospondin family.

Background :

Cartilage oligomeric matrix protein is a protein that in humans is encoded by the COMP gene. The sequences of rat and bovine COMP indicate that it is a member of the thrombospondin gene family. By Southern blot analysis of a somatic cell hybrid DNA panel and by isotopic in situ hybridization, human COMP gene was mapped to 19p13.1, and the murine COMP gene was mapped to the central region of mouse chromosome 8 by use of an interspecific backcross mapping panel. COMP is a marker of cartilage turnover.

Research Category :

Cell Biology, Cell Cycle, Cell Differentiation, Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Signal Transduction, Stem Cells, Structures