Human Aggrecan/ACAN ELISA Kit PicoKine® | Boster EK0909 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Aggrecan/ACAN ELISA Kit PicoKine®

catalog :

EK0909

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0909

Product Name :

Human Aggrecan/ACAN ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Aggrecan ELISA Kit PicoKine® (96 Tests). Quantitate Human ACAN in cell culture supernatants, serum and urine. Sensitivity: 50pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

ACAN

Uniprot ID :

P16112

Immunogen :

Expression system for standard: NS0; Immunogen sequence: V20-R675

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

1.56 ng/ml - 100 ng/ml

Sensitivity :

<50 pg/ml

Sample Type :

cell culture supernatants, serum and urine

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Aggrecan core protein

Synonyms :

Aggrecan core protein;Cartilage-specific proteoglycan core protein;CSPCP;Chondroitin sulfate proteoglycan core protein 1;Chondroitin sulfate proteoglycan 1;Aggrecan core protein 2;ACAN;AGC1, CSPG1, MSK16;

Protein Name :

Aggrecan core protein

Molecular Weight :

250193 MW

Protein Function :

This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix .

Tissue Specificity :

Restricted to cartilages.

Background :

Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is a protein that in humans is encoded by the ACAN gene. It is a critical component for cartilage structure and the function of joints. Aggrecan provides intervertebral disc and cartilage with the ability to resist compressive loads. The localized high concentrations of aggrecan provide the osmotic properties necessary for normal tissue function with the GAGs producing the swelling pressure that counters compressive loads on the tissue. This functional ability is dependent on a high GAG/aggrecan concentration being present in the tissue extracellular matrix. Also, Aggrecan plays an important role in the organization of the extracellular spaces between neurons in the brain.

Research Category :

Cytoskeleton / Ecm, Ecm Proteins, Extracellular Matrix, Mesenchymal Stem Cells, Signal Transduction, Stem Cells