Human TLR3/Toll-like receptor 3 ELISA Kit PicoKine® | Boster EK0907 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TLR3/Toll-like receptor 3 ELISA Kit PicoKine®

catalog :

EK0907

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0907

Product Name :

Human TLR3/Toll-like receptor 3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TLR3/Toll-like receptor 3 ELISA Kit PicoKine® (96 Tests). Quantitate Human TLR3 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TLR3

Uniprot ID :

O15455

Immunogen :

Expression system for standard: NS0; Immunogen sequence: K27-S711

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Toll-like receptor 3

Synonyms :

Toll-like receptor 3;CD283;TLR3;

Protein Name :

Toll-like receptor 3

Molecular Weight :

103829 MW

Protein Function :

Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR3 is a nucleotide-sensing TLR which is activated by double-stranded RNA, a sign of viral infection. Acts via the adapter TRIF/TICAM1, leading to NF-kappa-B activation, IRF3 nuclear translocation, cytokine secretion and the inflammatory response.

Subcellular Localization :

Endoplasmic reticulum membrane; Single-pass type I membrane protein. Endosome membrane.

Tissue Specificity :

Expressed at high level in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors. TLR3 is the TLR that is expressed most strongly in the brain, especially in astrocytes, glia, and neurons.

Sequence Similarities :

Belongs to the Toll-like receptor family.

Background :

Toll-like receptor 3 (TLR3) also known as CD283 (cluster of differentiation 283) is a protein that in humans is encoded by the TLR3 gene. The TLR3 gene was mapped to chromosome 4q35 by fluorescence in situ hybridization. TLR3 specifically recognizes double-stranded RNA (dsRNA) and induces multiple intracellular events responsible for innate antiviral immunity against a number of viral infections.

Research Category :

Chemokines, Host Virus Interaction, Immune System Diseases, Immunoglobulins, Immunology, Innate Immunity, Interspecies Interaction, Macrophage / Inflamm., Microbiology, Nfkb Pathway, Nuclear Signaling, Receptors, Signal Transduction, Signaling Pathway, Tlr Signaling