Human Angiostatin Kringle 1-3/PLG ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Angiostatin Kringle 1-3/PLG ELISA Kit PicoKine®

catalog :

EK0905

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0905

Product Name :

Human Angiostatin Kringle 1-3/PLG ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Angiostatin Kringle 1-3/PLG ELISA Kit PicoKine® (96 Tests). Quantitate Human PLG in cell culture supernatants, serum and plasma (heparin, EDTA) . Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PLG

Uniprot ID :

P00747

Immunogen :

Expression system for standard: NS0; Immunogen sequence: V98-S355 (K1-3)

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Plasminogen

Synonyms :

Plasminogen;3.4.21.7;Plasmin heavy chain A;Activation peptide;Angiostatin;Plasmin heavy chain A, short form;Plasmin light chain B;PLG;

Protein Name :

Plasminogen

Molecular Weight :

90569 MW

Protein Function :

Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.

Subcellular Localization :

Secreted . Locates to the cell surface where it is proteolytically cleaved to produce the active plasmin. Interaction with HRG tethers it to the cell surface.

Tissue Specificity :

Present in plasma and many other extracellular fluids. It is synthesized in the liver.

Sequence Similarities :

Belongs to the peptidase S1 family. Plasminogen subfamily.

Background :

Ang K1-3 is a single, non-glycosylated polypeptide chain containing 259 amino acids. It represents a proteolytic fragment of plasminogen containing the first three kringle structures. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth. It displays increased inhibitory activity (ED₅₀ =70 nM) relative to kringles 1-4 (ED₅₀ = 135 nM).

Research Category :

Cardiovascular, Cell Biology, Platelets, Protease Inhibitors, Proteolysis / Ubiquitin, Proteolytic Enzymes