Human KLK1/Kallikrein 1 ELISA Kit PicoKine® | Boster EK0903 product information

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human KLK1/Kallikrein 1 ELISA Kit PicoKine®

catalog :

EK0903

quantity :

96 wells/kit, with removable strips.

price :

420 USD

more info or order :

Boster product webpage

citations: 1

Reference
Scarisbrick I, Linbo R, Vandell A, Keegan M, Blaber S, Blaber M, et al. Kallikreins are associated with secondary progressive multiple sclerosis and promote neurodegeneration. Biol Chem. 2008;389:739-45 pubmed publisher

image

image 1 :

Human KLK1 PicoKine ELISA Kit standard curve

product information

SKU :

EK0903

Product Name :

Human KLK1/Kallikrein 1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Price :

420 USD

Description :

Human KLK1/Kallikrein 1 ELISA Kit PicoKine® (96 Tests). Quantitate Human KLK1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

KLK1

Uniprot ID :

P06870

Immunogen :

Expression system for standard: NS0; Immunogen sequence: I25-S262

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Kallikrein-1

Synonyms :

Kallikrein-1;3.4.21.35;Kidney/pancreas/salivary gland kallikrein;Tissue kallikrein;KLK1;

Protein Name :

Kallikrein-1

Molecular Weight :

28890 MW

Protein Function :

Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.

Tissue Specificity :

Isoform 2 is expressed in pancreas, salivary glands, kidney, colon, prostate gland, testis, spleen and the colon adenocarcinoma cell line T84.

Sequence Similarities :

Belongs to the peptidase S1 family. Kallikrein subfamily.

Background :

Kallikrein-1, also known as tissue kallikrein, is a protein that in humans is encoded by the KLK1 gene. This serine protease generates Lys-bradykinin by specific proteolysis of kininogen-1. KLK1 is a member of the peptidase S1 family. Its gene is mapped to 19q13.3. In all, it has got 262-amino acids which contain a putative signal peptide, followed by a short activating peptide and the protease domain. The protein is mainly found in kidney, pancreas, and salivary gland, showing a unique pattern of tissue-specific expression relative to other members of the family. KLK1 is implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Cell Biology, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Proteolysis / Ubiquitin, Proteolytic Enzymes, Serum Proteins, Signal Transduction

more info or order :

Boster product webpage