Human PEDF/SerpinF1 ELISA Kit PicoKine® | Boster EK0896 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human PEDF/SerpinF1 ELISA Kit PicoKine®

catalog :

EK0896

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0896

Product Name :

Human PEDF/SerpinF1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human PEDF/SerpinF1 ELISA Kit PicoKine® (96 Tests). Quantitate Human SERPINF1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 20pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

SERPINF1

Uniprot ID :

P36955

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M1-P418

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<20 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Pigment epithelium-derived factor

Synonyms :

Pigment epithelium-derived factor;PEDF;Cell proliferation-inducing gene 35 protein;EPC-1;Serpin F1;SERPINF1;PEDF;PIG35;

Protein Name :

Pigment epithelium-derived factor

Molecular Weight :

46312 MW

Protein Function :

Neurotrophic protein; induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.

Subcellular Localization :

Secreted . Melanosome . Enriched in stage I melanosomes.

Tissue Specificity :

Retinal pigment epithelial cells and blood plasma.

Background :

Pigment epithelium-derived factor (PEDF) is also known as serpin F1 (SERPINF1). In humans, it is encoded by the SERPINF1 gene. PEDF has a variety of functions including antiangiogenic, antitumorigenic, and neurotrophic properties. It suppresses retinal neovascularization and endothelial cell proliferation. And Antiangiogenic function is also conferred by PEDF through inhibition of both VEGFR-1 and VEGFR-2. In addition, the antitumorigenic effects of PEDF are not only due to inhibition of supporting vasculature, but also due to effects on the cancer cells themselves. PEDF is shown to inhibit cancer cell proliferation and increase apoptosis via the FAS/FASL pathway. Expression of PEDF in the human retina is found at 7.4 weeks of gestation, suggesting it may play a role in retinal neuron differentiation.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Invasion/Microenvironment, Neurogenesis, Neurology Process, Neuroscience, Sensory System, Visual System