Human P53 ELISA Kit PicoKine® | Boster EK0895 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human P53 ELISA Kit PicoKine®

catalog :

EK0895

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0895

Product Name :

Human P53 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human P53 ELISA Kit PicoKine® (96 Tests). Quantitate Human TP53 in cell lysates. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TP53

Uniprot ID :

K7PPA8

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M1-D393

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell lysate

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cellular tumor antigen p53

Synonyms :

Cellular tumor antigen p53 ;TP53 ;

Protein Name :

Cellular tumor antigen p53

Molecular Weight :

43653 MW

Protein Function :

Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression.

Subcellular Localization :

Cytoplasm. Nucleus.

Background :

P53 (also known as protein 53 or tumor protein 53), is a tumor suppressor protein that in humans is encoded by the TP53 gene. The human P53 gene is mapped to chromosome 17. Human p53 is 393 amino acids long and has seven domains. It runs as a 53-kilodalton (kDa) protein on SDS-PAGE. The pattern of p53 splicing was specific for brain areas and for individuals. And human kidney and heart expressed only full-length p53. It has played a vital role in conserving stability by preventing genome mutation.

Research Category :

Apoptosis, Cell Biology, Intracellular, P53 Pathway