Human HO-1/HMOX1/HSP32 ELISA Kit PicoKine® | Boster EK0888 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human HO-1/HMOX1/HSP32 ELISA Kit PicoKine®

catalog :

EK0888

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0888

Product Name :

Human HO-1/HMOX1/HSP32 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human HO-1/HMOX1/HSP32 ELISA Kit PicoKine® (96 Tests). Quantitate Human HMOX1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

HMOX1

Uniprot ID :

P09601

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: M1-M288

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

93.7 pg/ml - 6,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Heme oxygenase 1

Synonyms :

Heme oxygenase 1;HO-1;1.14.99.3;HMOX1;HO, HO1;

Protein Name :

Heme oxygenase 1

Molecular Weight :

32819 MW

Protein Function :

Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.

Subcellular Localization :

Microsome . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side .

Tissue Specificity :

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level).

Background :

HMOX1 (heme oxygenase (decycling) 1) is a human gene that encodes for the enzyme heme oxygenase 1. It is localized to chromosome 22. Heme oxygenase, an essential enzyme in heme catabolism, cleaves heme to form biliverdin, which is subsequently converted to bilirubin by biliverdin reductase, and carbon monoxide, a putative neurotransmitter. Heme oxygenase activity is induced by its substrate heme and by various nonheme substances. Heme oxygenase occurs as 2 isozymes, an inducible heme oxygenase-1 and a constitutive heme oxygenase-2. HMOX1 and HMOX2 belong to the heme oxygenase family.

Research Category :

Alzheimer'S Disease, Atherosclerosis, Cancer, Cancer Metabolism, Cardiovascular, Epigenetics and Nuclear Signaling, Heart Disease, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Nfkb Pathway, Nuclear Signaling, Nuclear Signaling Pathways, Pathways And Processes, Platelets, Response To Hypoxia, Signal Transduction, Signaling Pathway, Vascular Inflammation, Vasculature