Human FLRG/FSTL3 ELISA Kit PicoKine® | Boster EK0869 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human FLRG/FSTL3 ELISA Kit PicoKine®

catalog :

EK0869

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0869

Product Name :

Human FLRG/FSTL3 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human FLRG/FSTL3 ELISA Kit PicoKine® (96 Tests). Quantitate Human FSTL3 in cell culture supernatants, serum, plasma (heparin, EDTA) , urine and human milk. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

FSTL3

Uniprot ID :

O95633

Immunogen :

Expression system for standard: NS0; Immunogen sequence: M27-V263

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), urine and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Follistatin-related protein 3

Synonyms :

Follistatin-related protein 3;Follistatin-like protein 3;Follistatin-related gene protein;FSTL3;FLRG;UNQ674/PRO1308;

Protein Name :

Follistatin-related protein 3

Molecular Weight :

27663 MW

Protein Function :

Isoform 1 or the secreted form is a binding and antagonizing protein for members of the TGF-beta family, such us activin, BMP2 and MSTN. Inhibits activin A-, activin B-, BMP2- and MSDT-induced cellular signaling; more effective on activin A than on activin B. Involved in bone formation; inhibits osteoclast differentiationc. Involved in hematopoiesis; involved in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. Isoform 2 or the nuclear form is probably involved in transcriptional regulation via interaction with MLLT10.

Subcellular Localization :

Isoform 1: Secreted.

Tissue Specificity :

Expressed in a wide range of tissues.

Sequence Similarities :

Contains 2 follistatin-like domains.

Background :

FSTL3 (Follistatin-Like 3) also known as FLRG or FOLLISTATIN-RELATED GENE, is a member of the follistatin-module protein family, which is composed of extracellular matrix-associated glycoproteins thought to act in a paracrine manner to bind morphogens or growth/differentiation factors and regulate their activity during development. The FSTL3 gene extends over 7 kbp and contains 5 exons. The FSTL3 gene was localized to chromosome 19p13. This gene involved in hematopoiesis and in differentiation of hemopoietic progenitor cells, increases hematopoietic cell adhesion to fibronectin and seems to contribute to the adhesion of hematopoietic precursor cells to the bone marrow stroma. It may have a role in leukemogenesis.

Research Category :

Growth Factors/Hormones, Hematopoietic Progenitors, Lymphoid, Mesenchymal Stem Cells, Signal Transduction, Stem Cells