Mouse IL-23 ELISA Kit PicoKine® | Boster EK0866 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse IL-23 ELISA Kit PicoKine®

catalog :

EK0866

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0866

Product Name :

Mouse IL-23 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse IL-23 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Il23a in cell culture supernatants, serum and plasma (heparin). Sensitivity: 2pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

IL23A

Uniprot ID :

Q9EQ14

Immunogen :

Expression system for standard: NS0; Immunogen sequence: (M23-S335) + (L20-A196)

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-23 subunit alpha

Synonyms :

Interleukin-23 subunit alpha;IL-23 subunit alpha;IL-23-A;Interleukin-23 subunit p19;IL-23p19;Il23a;

Protein Name :

Interleukin-23 subunit alpha

Molecular Weight :

22071 MW

Protein Function :

Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak- Stat signaling cascade, stimulates memory rather than naive T- cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.

Subcellular Localization :

Secreted . Secreted upon association with IL12B.

Tissue Specificity :

Secreted by activated dendritic cells (at protein level). Detected in various tissues with higher expression in polarized Th1 cells and activated macrophages.

Background :

Interleukin-23 subunit alpha (IL-23) is a protein that in humans is encoded by the IL23A gene. IL-23 is a heterodimeric cytokine consisting of two subunits, one called p40, which is shared with another cytokine, IL-12, and another called p19 (the IL-23 alpha subunit). IL-23 is an important part of the inflammatory response against infection. It promotes upregulation of the matrix metalloprotease MMP9, increases angiogenesis and reduces CD8+ T-cell infiltration. Recently, IL-23 has been implicated in the development of cancerous tumors. he International Radiation Hybrid Mapping Consortium mapped the p19 gene to chromosome 12 (stSG47812).