Mouse TNFSF4/OX40L ELISA Kit PicoKine® | Boster EK0858 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TNFSF4/OX40L ELISA Kit PicoKine®

catalog :

EK0858

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0858

Product Name :

Mouse TNFSF4/OX40L ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TNFSF4/OX40L ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Tnfsf4 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TNFSF4

Uniprot ID :

P43488

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S51-L198

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor ligand superfamily member 4

Synonyms :

Tumor necrosis factor ligand superfamily member 4;OX40 ligand;OX40L;CD252;Tnfsf4;Ox40l, Txgp1l;

Protein Name :

Tumor necrosis factor ligand superfamily member 4

Molecular Weight :

22255 MW

Protein Function :

Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production.

Subcellular Localization :

Membrane; Single-pass type II membrane protein.

Background :

OX40L is the ligand for CD134 and is expressed on such cells as DC2s enabling amplification of Th2 cell differentiation. OX40L has also been designated CD252. By analysis of an interspecific backcross, Baum et al. (1994) mapped the mouse Tnfsf4 gene to chromosome 1. Using fluorescence in situ hybridization, they localized the human TNFSF4 gene to 1q25, a region sharing homology of synteny with the portion of mouse chromosome 1 containing the Tnfsf4 gene.OX40L strongly inhibited the generation of IL-10-producing Tr1 cells induced by two physiologic stimuli, the inducible costimulatory ligand and immature dendritic cells. In addition, OX40L strongly inhibited IL-10 production and suppressive function of differentiated IL-10-producing Tr1 cells. Tnfsf4 underlies Ath1 in mice and that polymorphisms in its human homolog TNFSF4 increase the risk of myocardial infarction in humans.

Research Category :

Adaptive Immunity, Autoimmune, B Cells, Cell Type Markers, Cytokines, Immune System Diseases, Immunology, Innate Immunity, T Cells, Tnf Superfamily