Human Nidogen-1 / Entactin / NID-1 / NID1 ELISA Kit PicoKine®

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human Nidogen-1 / Entactin / NID-1 / NID1 ELISA Kit PicoKine®

catalog :

EK0856

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0856

Product Name :

Human Nidogen-1 / Entactin / NID-1 / NID1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human Nidogen-1 / Entactin / NID-1 / NID1 ELISA Kit PicoKine® (96 Tests). Quantitate Human NID1 in cell culture supernatants and serum. Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

NID1

Uniprot ID :

P14543

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L29-K1114

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Nidogen-1

Synonyms :

Nidogen-1;NID-1;Entactin;NID1;NID;

Protein Name :

Nidogen-1

Molecular Weight :

136377 MW

Protein Function :

Sulfated glycoprotein widely distributed in basement membranes and tightly associated with laminin. Also binds to collagen IV and perlecan. It probably has a role in cell- extracellular matrix interactions.

Subcellular Localization :

Secreted, extracellular space, extracellular matrix, basement membrane.

Sequence Similarities :

Contains 6 EGF-like domains.

Background :

Nidogen-1 (NID-1), also known as Entactin, is a protein that in humans is encoded by the NID1 gene. It is a member of the nidogen family of basement membrane glycoproteins. This gene is mapped to 1q42.3. Nidogen-1 is a component of the basement membrane alongside other components such as collagen type IV, proteoglycans (heparan sulfate and glycosaminoglycans), laminin and fibronectin. The protein interacts with several other components of basement membranes. Structurally it (along with perlecan) connects the networks formed by collagens and laminins to each other. It may also play a role in cell interactions with the extracellular matrix. Nidogen-1 also can serve as a bridge between the 2 most abundant molecules in the basement membrane: type IV collagen and laminin.