Human TREM-1 ELISA Kit PicoKine® | Boster EK0844 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human TREM-1 ELISA Kit PicoKine®

catalog :

EK0844

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0844

Product Name :

Human TREM-1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human TREM-1 ELISA Kit PicoKine® (96 Tests). Quantitate Human TREM1 in cell culture supernatants, lysates, tissue, serum and plasma (heparin or EDTA) . Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TREM1

Uniprot ID :

Q9NP99

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A21-R200

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, lysates, tissue, serum and plasma (heparin or EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

triggering receptor expressed on myeloid cells 1

Synonyms :

Triggering receptor expressed on myeloid cells 1; TREM-1; Triggering receptor expressed on monocytes 1; CD354; TREM1

Protein Function :

Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock.

Subcellular Localization :

Cell membrane. Single-pass type I membrane protein.

Tissue Specificity :

Highly expressed in adult liver, lung and spleen than in corresponding fetal tissue. Also expressed in the lymph node, placenta, spinal cord and heart tissues. Expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. Expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes. Strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Isoform 2 was detected in the lung, liver and mature monocytes.

Background :

Triggering receptor expressed on myeloid cells 1 is a protein that in humans is encoded by the TREM1 gene. It is mapped to 6p21.1. This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.

Research Category :

Immunology, Innate Immunity, Macrophage / Inflamm.