Mouse TNFSF11/RANKL ELISA Kit PicoKine® | Boster EK0843 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TNFSF11/RANKL ELISA Kit PicoKine®

catalog :

EK0843

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0843

Product Name :

Mouse TNFSF11/RANKL ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TNFSF11/RANKL ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Tnfsf11 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TNFSF11

Uniprot ID :

O35235

Immunogen :

Expression system for standard: NS0; Immunogen sequence: R72-D316

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor ligand superfamily member 11

Synonyms :

Tumor necrosis factor ligand superfamily member 11;Osteoclast differentiation factor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-B ligand;RANKL;TNF-related activation-induced cytokine;TRANCE;CD254;Tumor necrosis factor ligand superfamily member 11, membrane form;Tumor necrosis factor ligand superfamily member 11, soluble form;Tnfsf11;Opgl, Rankl, Trance;

Protein Name :

Tumor necrosis factor ligand superfamily member 11

Molecular Weight :

35003 MW

Protein Function :

Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Subcellular Localization :

Isoform 1: Cell membrane; Single-pass type II membrane protein.

Tissue Specificity :

Highly expressed in thymus and lymph nodes, but not in non-lymphoid tissues and is abundantly expressed in T- cells but not in B-cells. A high level expression is also seen in the trabecular bone and lung.

Background :

Receptor activator of nuclear factor kappa-B ligand (RANKL), also known as tumor necrosis factor ligand superfamily member 11 (TNFSF11), is a protein that in humans is encoded by the TNFSF11 gene. This gene encodes a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This gene is mapped to chromosome13q14.11. Targeted disruption of the related gene in mice led to severe osteopetrosis and a lack of osteoclasts. The deficient mice exhibited defects in early differentiation of T and B lymphocytes, and failed to form lobulo-alveolar mammary structures during pregnancy. This gene may play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy.

Research Category :

Adaptive Immunity, Atherosclerosis, Cardiovascular, Cytokines, Cytoskeleton / Ecm, Extracellular Matrix, Immunology, Innate Immunity, Signal Transduction, Structures, Tnf Superfamily