Human RANK ELISA Kit PicoKine® | Boster EK0829 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human RANK ELISA Kit PicoKine®

catalog :

EK0829

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0829

Product Name :

Human RANK ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human RANK ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF11A in cell culture supernatants and serum. Sensitivity: 2pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF11A

Uniprot ID :

Q9Y6Q6

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Q29-G213

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants and serum

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 11A

Synonyms :

Tumor necrosis factor receptor superfamily member 11A;Osteoclast differentiation factor receptor;ODFR;Receptor activator of NF-KB;CD265;TNFRSF11A;RANK;

Protein Name :

Tumor necrosis factor receptor superfamily member 11A

Molecular Weight :

66034 MW

Protein Function :

Receptor for TNFSF11/RANKL/TRANCE/OPGL; essential for RANKL-mediated osteoclastogenesis. Involved in the regulation of interactions between T-cells and dendritic cells.

Subcellular Localization :

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Ubiquitous expression with high levels in skeletal muscle, thymus, liver, colon, small intestine and adrenal gland.

Sequence Similarities :

Contains 4 TNFR-Cys repeats.

Background :

Receptor Activator of Nuclear Factor kappa B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain (residues 234-616), which contain three putative TRAF-binding domains (termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK. The standard in this kit is recombinant human RANK with the sequence of Q29-G213 aa. It is a dipolymer which compose of two chains, and the molecular weight of each is 48kda.

Research Category :

Cytoskeleton / Ecm, Extracellular Matrix, Growth Factors/Hormones, Immunology, Innate Immunity, Signal Transduction, Structures, Tnf Superfamily, Transmembrane, Vascular Inflammation