Mouse LOX-1/OLR1 ELISA Kit PicoKine® | Boster EK0825 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse LOX-1/OLR1 ELISA Kit PicoKine®

catalog :

EK0825

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0825

Product Name :

Mouse LOX-1/OLR1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse LOX-1/OLR1 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Olr1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 1pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

OLR1

Uniprot ID :

Q9EQ09

Immunogen :

Expression system for standard: NS0; Immunogen sequence: R60-I363

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Oxidized low-density lipoprotein receptor 1

Synonyms :

Oxidized low-density lipoprotein receptor 1;Ox-LDL receptor 1;Lectin-like oxidized LDL receptor 1;LOX-1;Lectin-like oxLDL receptor 1;Lectin-type oxidized LDL receptor 1;Oxidized low-density lipoprotein receptor 1, soluble form;Olr1;Lox1;

Protein Name :

Oxidized low-density lipoprotein receptor 1

Molecular Weight :

41643 MW

Protein Function :

Receptor that mediates the recognition, internalization and degradation of oxidatively modified low density lipoprotein (oxLDL) by vascular endothelial cells. OxLDL is a marker of atherosclerosis that induces vascular endothelial cell activation and dysfunction, resulting in pro-inflammatory responses, pro- oxidative conditions and apoptosis. Its association with oxLDL induces the activation of NF-kappa-B through an increased production of intracellular reactive oxygen and a variety of pro- atherogenic cellular responses including a reduction of nitric oxide (NO) release, monocyte adhesion and apoptosis. In addition to binding oxLDL, it acts as a receptor for the HSP70 protein involved in antigen cross-presentation to naive T-cells in dendritic cells, thereby participating in cell-mediated antigen cross-presentation. Also involved in inflammatory process, by acting as a leukocyte-adhesion molecule at the vascular interface in endotoxin-induced inflammation. Also acts as a receptor for advanced glycation end (AGE) products, activated platelets, monocytes, apoptotic cells and both Gram-negative and Gram- positive bacteria (By similarity).

Subcellular Localization :

Cell membrane ; Lipid-anchor . Cell membrane ; Single-pass type II membrane protein . Membrane raft . Secreted . A secreted form also exists. Localization to membrane rafts requires palmitoylation (By similarity).

Sequence Similarities :

Contains 1 C-type lectin domain.

Background :

Oxidized low-density lipoprotein receptor 1 (Ox-LDL receptor 1) also known as lectin-type oxidized LDL receptor 1 (LOX-1) is a protein that in humans is encoded by the OLR1 gene. It belongs to the C-type lectin superfamily. The LOX1 gene is mapped to to 12p13-p12. The protein has got the amino acids of 363. It can be detected in various tissues, highly expressed in placenta. This protein may be involved in the regulation of Fas-induced apoptosis and play a role as a scavenger receptor. The standards of this kit are recombinant mouse LOX-1 (R60-I363), with molecular weight of 36.3kDa.

Research Category :

Cardiovascular, Cell Biology, Fatty Acids, Lipid Metabolism, Lipids / Lipoproteins, Metabolism, Oxidative Stress, Signal Transduction