Mouse Mer ELISA Kit PicoKine® | Boster EK0811 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse Mer ELISA Kit PicoKine®

catalog :

EK0811

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0811

Product Name :

Mouse Mer ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse Mer ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Mertk in cell culture supernatants, cell lysates and serum. Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

MERTK

Uniprot ID :

Q60805

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E23-F498

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

78 pg/ml - 5,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates and serum

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tyrosine-protein kinase Mer

Synonyms :

Tyrosine-protein kinase Mer;2.7.10.1;Proto-oncogene c-Mer;Receptor tyrosine kinase MerTK;Mertk;Mer;

Protein Name :

Tyrosine-protein kinase Mer

Molecular Weight :

110157 MW

Protein Function :

Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll- like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Subcellular Localization :

Membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Expressed predominantly in the hematopoietic lineages: macrophages, NK cells, NKT cells, dendritic cells and platelets.

Sequence Similarities :

Belongs to the protein kinase superfamily. Tyr protein kinase family. AXL/UFO subfamily.

Background :

Proto-oncogene tyrosine-protein kinase MER, also called MERTK is an enzyme that in humans is encoded by the MERTK gene. This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. This gene is mapped to 2q13. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. This gene also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.

Research Category :

Protein Phosphorylation, Receptor Tyrosine Kinases, Sensory System, Signal Transduction, Tyrosine Kinases, Visual System