Mouse MBL2/MPB-C ELISA Kit PicoKine® | Boster EK0806 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse MBL2/MPB-C ELISA Kit PicoKine®

catalog :

EK0806

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0806

Product Name :

Mouse MBL2/MPB-C ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse MBL2/MPB-C ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Mbl2 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

MBL2

Uniprot ID :

P41317

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E19-D244

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

312 pg/ml - 20,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Mannose-binding protein C

Synonyms :

Mannose-binding protein C;MBP-C;Mannan-binding protein;RA-reactive factor P28A subunit;RARF/P28A;Mbl2;

Protein Name :

Mannose-binding protein C

Molecular Weight :

25957 MW

Protein Function :

Calcium-dependent lectin involved in innate immune defense. Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages (By similarity).

Subcellular Localization :

Secreted .

Sequence Similarities :

Contains 1 C-type lectin domain.

Background :

MBL2, also called mannose-binding lectin (protein C) 2, soluble or Mannose-binding lectin (MBL) is a lectin that is instrumental in innate immunity. MBL2 is mapped to chromosome 10q11.2-q21. It belongs to the class of collectins in the C-type lectin superfamily, whose function appears to be pattern recognition in the first line of defense in the pre-immune host. MBL2 recognizes carbohydrate patterns, found on the surface of a large number of pathogenic micro-organisms, including bacteria, viruses, protozoa and fungi. Binding MBL2 to a micro-organism results in activation of the lectin pathway of the complement system. Another important function of MBL2 is that this molecule binds senescent and apoptotic cells and enhances engulfment of whole, intact apoptotic cells, as well as cell debris by phagocytes.

Research Category :

Complement, Immunology, Innate Immunity