Human IL-17F/Interleukin-17F ELISA Kit PicoKine® | Boster EK0795 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-17F/Interleukin-17F ELISA Kit PicoKine®

catalog :

EK0795

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0795

Product Name :

Human IL-17F/Interleukin-17F ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL-17F ELISA Kit PicoKine® (96 Tests). Quantitate Human IL17F in cell culture supernatants, serum and plasma (heparin or EDTA) . Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL17F

Uniprot ID :

Q96PD4

Immunogen :

Expression system for standard: NS0; Immunogen sequence: R31-Q163

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin or EDTA)

Capture/Detection Antibodies :

A monoclonal antibody from mouse, a biotinylated detection polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

interleukin 17F

Synonyms :

Interleukin-17F; IL-17F; Cytokine ML-1; IL17F

Protein Function :

Ligand for IL17RA and IL17RC. The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC. Involved in stimulating the production of other cytokines such as IL6, IL8 and CSF2, and in regulation of cartilage matrix turnover. Also involved in stimulating the proliferation of peripheral blood mononuclear cells and T-cells and in inhibition of angiogenesis. Plays a role in the induction of neutrophilia in the lungs and in the exacerbation of antigen-induced pulmonary allergic inflammation.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in activated, but not resting, CD4+ T-cells and activated monocytes.

Background :

Members of the interleukin-17 family, such as IL17F, are involved in the regulation of normal versus aberrant T-cell responses. It is mapped to 6p12.2. The protein encoded by this gene is a cytokine that shares sequence similarity with IL17. This cytokine is expressed by activated T cells, and has been shown to stimulate the production of several other cytokines, including IL6, IL8, and CSF2/GM_CSF. This cytokine is also found to inhibit the angiogenesis of endothelial cells and induce endothelial cells to produce IL2, TGFB1/TGFB, and monocyte chemoattractant protein-1.

Research Category :

Angiogenesis, Cancer, Cardiovascular, Cytokines, Immunology, Innate Immunity, Interleukins, Invasion/Microenvironment