Human IL-17E/IL-25 ELISA Kit PicoKine® | Boster EK0793 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-17E/IL-25 ELISA Kit PicoKine®

catalog :

EK0793

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0793

Product Name :

Human IL-17E/IL-25 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL-17E/IL-25 ELISA Kit PicoKine® (96 Tests). Quantitate Human IL25 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL25

Uniprot ID :

Q9H293

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: Y33-G177

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-25

Synonyms :

Interleukin-25;IL-25;Interleukin-17E;IL-17E;IL25;IL17E;UNQ3120/PRO10272;

Protein Name :

Interleukin-25

Molecular Weight :

20330 MW

Protein Function :

Induces activation of NF-kappa-B and stimulates production of the proinflammatory chemokine IL-8. Proinflammatory cytokine favoring Th2-type immune responses.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed at low levels in several tissues, including brain, kidney, lung, prostate, testis, spinal cord, adrenal gland, and trachea.

Sequence Similarities :

Belongs to the IL-17 family.

Background :

Interleukin-25 (IL-25), also known as interleukin-17E (IL-17E), is a protein that in humans is encoded by the IL25 gene. It is a cytokine that belongs to the IL-17 cytokine family and mapped to 14q11.2. IL-25 is secreted by type 2 helper T cells (Th2) and mast cells. It has been found that IL-25 can induce Th2-type cytokine expression and production by non-T, non-B accessory cells that express high levels of major histocompatibility complex class II and low levels of Cd11c. This cytokine also can induce NF-κB activation, and stimulate the production of IL8. What’s more, IL-25 is an important molecule controlling immunity of the gut and has been implicated in chronic inflammation associated with the gastrointestinal tract.

Research Category :

Cytokines, Immunology, Innate Immunity, Interleukins