Mouse IL-17C ELISA Kit PicoKine® | Boster EK0790 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse IL-17C ELISA Kit PicoKine®

catalog :

EK0790

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0790

Product Name :

Mouse IL-17C ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse IL-17C ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Il17c in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

IL17C

Uniprot ID :

Q8K4C5

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: D17-Q194

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-17C

Synonyms :

Interleukin-17C;Il-17c;Cytokine CX2;Il17c;

Protein Name :

Interleukin-17C

Molecular Weight :

21592 MW

Protein Function :

Cytokine that plays a crucial role in innate immunity of the epithelium, including to intestinal bacterial pathogens, in an autocrine manner. Stimulates the production of antibacterial peptides and proinflammatory molecules for host defense by signaling through the NFKB and MAPK pathways. Acts synergically with IL22, TNF and IL1B in inducing antibacterial peptides. May have protective function by maintaining epithelial homeostasis after an inflammatory challenge, such as that caused in the intestine by dextran sulfate sodium in a colitis model. May also promote an inflammatory phenotype, such as skin in a psoriasis model. Enhanced IL17C/IL17RE signaling may also lead to greater susceptibility to autoimmune diseases, such as autoimmune encephalitis.

Subcellular Localization :

Secreted .

Tissue Specificity :

Expressed by epithelial cells after bacterial challenge. Low expression, if any, in lymphocytes.

Sequence Similarities :

Belongs to the IL-17 family.

Background :

IL17C, also known as CX2, is a protein that in humans is encoded by the IL17C gene. IL17C is mapped to 16q24.3. The protein encoded by this gene is a T cell-derived cytokine that shares the sequence similarity with IL17. This cytokine was reported to stimulate the release of tumor necrosis factor alpha and interleukin 1 beta from a monocytic cell line. The expression of this cytokine was found to be restricted to activated T cells. IL17C is an essential autocrine cytokine regulating innate epithelial immune responses. It also plays an important role in the pathogenesis of inflammatory arthritis.

Research Category :

Adaptive Immunity, Autoimmune, Cytokines, Immune System Diseases, Immunology, Innate Immunity, Interleukins