Human IL-17RA ELISA Kit PicoKine® | Boster EK0784 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human IL-17RA ELISA Kit PicoKine®

catalog :

EK0784

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0784

Product Name :

Human IL-17RA ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human IL-17RA ELISA Kit PicoKine® (96 Tests). Quantitate Human IL17RA in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

IL17RA

Uniprot ID :

Q96F46

Immunogen :

Expression system for standard: NS0; Immunogen sequence: L33-W320

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Interleukin-17 receptor A

Synonyms :

Interleukin-17 receptor A;IL-17 receptor A;IL-17RA;CDw217;CD217;IL17RA;IL17R;

Protein Name :

Interleukin-17 receptor A

Molecular Weight :

96122 MW

Protein Function :

Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:19838198, PubMed:17911633). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848). Activation of IL17RA leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1, CXCL8/IL8 and IL6 (PubMed:16785495, PubMed:17911633, PubMed:18684971).

Subcellular Localization :

Isoform 1: Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Widely expressed.

Background :

Interleukin 17 receptor A, also known as IL17RA and CDw217 (cluster of differentiation w217), is a human gene. The IL17R gene is mapped to 22q11.22-q11.23 by radiation hybrid analysis. Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The protein encoded by this gene is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Also, it is showed that mouse Il17r bound HSV-13 and mouse Il17. Recombinant soluble Il17r inhibited mitogen-induced T-cell proliferation and Il2 production.

Research Category :

Cytokines, Immunology, Innate Immunity, Interleukins, Macrophage / Inflamm.