Human HBEGF ELISA Kit PicoKine® | Boster EK0770 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human HBEGF ELISA Kit PicoKine®

catalog :

EK0770

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0770

Product Name :

Human HBEGF ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human HBEGF ELISA Kit PicoKine® (96 Tests). Quantitate Human HBEGF in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

HBEGF

Uniprot ID :

Q99075

Immunogen :

Expression system for standard: NS0; Immunogen sequence: D63-L148

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

7.8 pg/ml - 500 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Proheparin-binding EGF-like growth factor

Synonyms :

Proheparin-binding EGF-like growth factor;Heparin-binding EGF-like growth factor;HB-EGF;HBEGF;Diphtheria toxin receptor;DT-R;HBEGF;DTR, DTS, HEGFL;

Protein Name :

Proheparin-binding EGF-like growth factor

Molecular Weight :

23067 MW

Protein Function :

Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Subcellular Localization :

Heparin-binding EGF-like growth factor: Secreted, extracellular space. Mature HB-EGF is released into the extracellular space and probably binds to a receptor.

Sequence Similarities :

Contains 1 EGF-like domain.

Background :

HBEGF (Heparin-binding EGF-like growth factor), also known as HEGFL or DTR, is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. The HBEGF gene is assigned to chromosome 5, thus confirming the assignment of the gene on the basis of its role in relation to diphtheria toxin susceptibility. HB-EGF is an 87 amino acid glycoprotein which displays highly regulated gene expression. It has been shown to play a role in wound healing, cardiac hypertrophy and heart development and function. HB-EGF binding and activation of EGF receptors plays a critical role during cardiac valve tissue development and the maintenance of normal heart function in adults.

Research Category :

Angiogenesis, Cancer, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Signal Transduction