Mouse TNFRSF18/GITR ELISA Kit PicoKine® | Boster EK0769 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse TNFRSF18/GITR ELISA Kit PicoKine®

catalog :

EK0769

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0769

Product Name :

Mouse TNFRSF18/GITR ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse TNFRSF18/GITR ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Tnfrsf18 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

TNFRSF18

Uniprot ID :

O35714

Immunogen :

Expression system for standard: NS0; Immunogen sequence: S22-H153

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

62.5 pg/ml - 4,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 18

Synonyms :

Tumor necrosis factor receptor superfamily member 18;Glucocorticoid-induced TNFR-related protein;CD357;Tnfrsf18;Gitr;

Protein Name :

Tumor necrosis factor receptor superfamily member 18

Molecular Weight :

25334 MW

Protein Function :

Receptor for TNFSF18. Seems to be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. Mediated NF-kappa-B activation via the TRAF2/NIK pathway (By similarity).

Subcellular Localization :

Isoform A: Cell membrane; Single-pass type I membrane protein.

Tissue Specificity :

Preferentially expressed in activated T lymphocytes.

Background :

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. This gene is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Research Category :

Innate Immunity, Signal Transduction