Human CSF3R/G-CSF R ELISA Kit PicoKine® | Boster EK0766 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CSF3R/G-CSF R ELISA Kit PicoKine®

catalog :

EK0766

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0766

Product Name :

Human CSF3R/G-CSF R ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CSF3R/G-CSF R ELISA Kit PicoKine® (96 Tests). Quantitate Human CSF3R in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

CSF3R

Uniprot ID :

Q99062

Immunogen :

Expression system for standard: NS0; Immunogen sequence: E25-P621

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Granulocyte colony-stimulating factor receptor

Synonyms :

Granulocyte colony-stimulating factor receptor;G-CSF receptor;G-CSF-R;CD114;CSF3R;GCSFR;

Protein Name :

Granulocyte colony-stimulating factor receptor

Molecular Weight :

92156 MW

Protein Function :

Receptor for granulocyte colony-stimulating factor (CSF3), essential for granulocytic maturation. Plays a crucial role in the proliferation, differientation and survival of cells along the neutrophilic lineage. In addition it may function in some adhesion or recognition events at the cell surface.

Subcellular Localization :

Isoform 2: Secreted .

Tissue Specificity :

One or several isoforms have been found in myelogenous leukemia cell line KG-1, leukemia U-937 cell line, in bone marrow cells, placenta, and peripheral blood granulocytes. Isoform GCSFR-2 is found only in leukemia U-937 cells. Isoform GCSFR-3 is highly expressed in placenta.

Background :

The granulocyte colony-stimulating factor receptor (G-CSF-R), also known as CD114 (Cluster of Differentiation 114), is a protein that in humans is encoded by the CSF3R gene. It is mapped to 1p35-p34.3. G-CSF-R is a cell-surface receptor for the granulocyte colony-stimulating factor (G-CSF). And the G-CSF-R is a transmembrane receptor that consists of an extracellular ligand-binding portion, a transmembrane domain, and the cytoplasmic portion that is responsible for signal transduction. In addition, GCSF-R ligand-binding is associated with dimerization of the receptor and signal transduction through proteins including Jak, Lyn, STAT, andErk1/2.

Research Category :

Cancer, Cytokines, Hematopoietic Progenitors, Immunology, Innate Immunity, Oncoproteins, Oncoproteins/Suppressors, Stem Cells, Surface Molecules