Human FGF23 ELISA Kit PicoKine® | Boster EK0759 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human FGF23 ELISA Kit PicoKine®

catalog :

EK0759

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0759

Product Name :

Human FGF23 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human FGF23 ELISA Kit PicoKine® (96 Tests). Quantitate Human FGF23 in cell culture supernatants, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

FGF23

Uniprot ID :

Q9GZV9

Immunogen :

Expression system for standard: NS0; Immunogen sequence: Y25-I251

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

15.6 pg/ml - 1,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

fibroblast growth factor 23

Synonyms :

Fibroblast growth factor 23; FGF-23; Phosphatonin; Tumor-derived hypophosphatemia-inducing factor; Fibroblast growth factor 23 N-terminal peptide; Fibroblast growth factor 23 C-terminal peptide; FGF23; HYPF; UNQ3027/PRO9828

Protein Function :

Regulator of phosphate homeostasis. Inhibits renal tubular phosphate transport by reducing SLC34A1 levels. Upregulates EGR1 expression in the presence of KL (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism. Negatively regulates osteoblast differentiation and matrix mineralization.

Subcellular Localization :

Secreted

Tissue Specificity :

Expressed in osteogenic cells particularly during phases of active bone remodeling. In adult trabecular bone, expressed in osteocytes and flattened bone-lining cells (inactive osteoblasts).

Background :

Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. It is a member of the fibroblast growth factor (FGF) family which is responsible for phosphate metabolism. The main function of FGF23 seems to be regulation of phosphate concentration in plasma. FGF23 is secreted by Osteocytes in response to elevated Calcitriol. And it acts on the kidneys, where it decreases the expression of NPT2, a sodium-phosphate cotransporter in the proximal tubule. Thus, FGF23 decreases the reabsorption and increases excretion of phosphate. Also, FGF23 may suppress 1-alpha-hydroxylase, reducing its ability to activate vitamin D and subsequently impairing calcium absorption.

Research Category :

Cancer, Cytoskeleton / Ecm, Developmental Biology, Extracellular Matrix, Growth Factors, Growth Factors/Hormones, Lineage Markers, Lineage Specification, Signal Transduction, Stem Cells, Structures