Human EMMPRIN/CD147/BSG ELISA Kit PicoKine® | Boster EK0751 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human EMMPRIN/CD147/BSG ELISA Kit PicoKine®

catalog :

EK0751

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0751

Product Name :

Human EMMPRIN/CD147/BSG ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human EMMPRIN/CD147/BSG ELISA Kit PicoKine® (96 Tests). Quantitate Human BSG in cell culture supernatants, serum, plasma (heparin, EDTA) , saliva, urine and human milk. Sensitivity: 2pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

BSG

Uniprot ID :

P35613

Immunogen :

Expression system for standard: NS0; Immunogen sequence: T25-H205

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<2 pg/ml

Sample Type :

cell culture supernatants, serum, plasma (heparin, EDTA), saliva, urine and human milk

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Basigin

Synonyms :

Basigin;5F7;Collagenase stimulatory factor;Extracellular matrix metalloproteinase inducer;EMMPRIN;Leukocyte activation antigen M6;OK blood group antigen;Tumor cell-derived collagenase stimulatory factor;TCSF;CD147;BSG;UNQ6505/PRO21383;

Protein Name :

Basigin

Molecular Weight :

42200 MW

Protein Function :

Plays an important role in targeting the monocarboxylate transporters SLC16A1, SLC16A3 and SLC16A8 to the plasma membrane. Plays pivotal roles in spermatogenesis, embryo implantation, neural network formation and tumor progression. Stimulates adjacent fibroblasts to produce matrix metalloproteinases (MMPS). Seems to be a receptor for oligomannosidic glycans. In vitro, promotes outgrowth of astrocytic processes.

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein . Melanosome . Colocalizes with SLC16A1 and SLC16A8. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Tissue Specificity :

Present only in vascular endothelium in non- neoplastic regions of the brain, whereas it is present in tumor cells but not in proliferating blood vessels in malignant gliomas.

Sequence Similarities :

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

Background :

Basigin is a member of the immunoglobulin superfamily that is also known as EMMPRIN, short for extracellular matrix metalloproteinase inducer, and recently has been designated CD147 (cluster of differentiation 147). It is a member of the immunoglobulin superfamily, with a structure related to the putative primordial form of the family. As members of the immunoglobulin superfamily play fundamental roles in intercellular recognition involved in various immunologic phenomena, differentiation, and development, basigin is thought also to play a role in intercellular recognition (Miyauchi et al., 1991; Kanekura et al., 1991).This protein is a determinant for the Ok blood group system. Basigin is a type I integral membrane receptor that has many ligands, including the cyclophilin (CyP) proteins Cyp-A and CyP-B and certain integrins. It is expressed by many cell types, including epithelial cells, endothelial cells and leukocytes.

Research Category :

Cancer, Cancer Metabolism, Carbohydrate Metabolism, Cytoskeleton / Ecm, Ecm Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Of Carbohydrates, Neuroscience, Pathways And Processes, Sensory System, Signal Transduction, Visual System