Human DCR3/TNFRSF6B ELISA Kit PicoKine® | Boster EK0748 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human DCR3/TNFRSF6B ELISA Kit PicoKine®

catalog :

EK0748

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0748

Product Name :

Human DCR3/TNFRSF6B ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human DCR3/TNFRSF6B ELISA Kit PicoKine® (96 Tests). Quantitate Human TNFRSF6B in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

TNFRSF6B

Uniprot ID :

O95407

Immunogen :

Expression system for standard: NS0; Immunogen sequence: V24-H300

Cross-reactivity :

No cross reactivity with other proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

monoclonal antibody from mouse, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Tumor necrosis factor receptor superfamily member 6B

Synonyms :

Tumor necrosis factor receptor superfamily member 6B;Decoy receptor 3;DcR3;Decoy receptor for Fas ligand;M68;TNFRSF6B;DCR3, TR6;UNQ186/PRO212;

Protein Name :

Tumor necrosis factor receptor superfamily member 6B

Molecular Weight :

32680 MW

Protein Function :

Decoy receptor that can neutralize the cytotoxic ligands TNFS14/LIGHT, TNFSF15 and TNFSF6/FASL. Protects against apoptosis.

Subcellular Localization :

Secreted.

Tissue Specificity :

Detected in fetal lung, brain and liver. Detected in adult stomach, spinal cord, lymph node, trachea, spleen, colon and lung. Highly expressed in several primary tumors from colon, stomach, rectum, esophagus and in SW480 colon carcinoma cells.

Background :

Decoy receptor 3 (Dcr3), also known as tumor necrosis factor receptor superfamily member 6B (TNFRSF6B), TR6 and M68, is a soluble protein of the tumor necrosis factor receptor superfamily which inhibits Fas ligand-inducedapoptosis. This gene belongs to the tumor necrosis factor receptor superfamily. It acts as a decoy receptor that competes with death receptors for ligand binding. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death and T cell activation as well as to induce angiogenesis via neutralization of TL1A. Overexpression of this gene has been noted in various tumors e.g. gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes.

Research Category :

Apoptosis, Cancer, Cell Biology, Cell Death, Cytokines, Immunology, Innate Immunity, Receptors