Human DAN/NBL1 ELISA Kit PicoKine® | Boster EK0746 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human DAN/NBL1 ELISA Kit PicoKine®

catalog :

EK0746

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0746

Product Name :

Human DAN/NBL1 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human DAN/NBL1 ELISA Kit PicoKine® (96 Tests). Quantitate Human NBL1 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 10pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

NBL1

Uniprot ID :

P41271

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A17-D181

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

125 pg/ml - 8,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

polyclonal antibody from goat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Neuroblastoma suppressor of tumorigenicity 1

Synonyms :

Neuroblastoma suppressor of tumorigenicity 1;DAN domain family member 1;Protein N03;Zinc finger protein DAN;NBL1;DAN, DAND1;

Protein Name :

Neuroblastoma suppressor of tumorigenicity 1

Molecular Weight :

19408 MW

Protein Function :

Possible candidate as a tumor suppressor gene of neuroblastoma. May play an important role in preventing cells from entering the final stage (G1/S) of the transformation process.

Subcellular Localization :

Secreted.

Tissue Specificity :

Most abundant in normal lung and meningioma.

Background :

Differential screening-selected gene aberrative in neuroblastoma (DAN) is a member of the DAN family of secreted glycoproteins that are putative BMP antagonists. The NBL1 gene, also known as DAN, is originally cloned from a normal rat fibroblast cDNA library by a differential screening method. The human DAN gene is mapped to chromosome 1p36.13-p36. It is found that the DAN gene possesses a tumor suppressive activity when overexpressed in v-src transformed cells.

Research Category :

Cancer, Growth Factors/Hormones, Oncoproteins/Suppressors, Signal Transduction, Tumor Suppressors