Mouse CXCL10/IP-10 ELISA Kit PicoKine® | Boster EK0736 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse CXCL10/IP-10 ELISA Kit PicoKine®

catalog :

EK0736

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0736

Product Name :

Mouse CXCL10/IP-10 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse CXCL10/IP-10 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Cxcl10 in cell culture supernatants, serum and plasma ( heparin). Sensitivity: 1pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CXCL10

Uniprot ID :

P17515

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: I22-P98

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<1 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

C-X-C motif chemokine 10

Synonyms :

C-X-C motif chemokine 10;10 kDa interferon gamma-induced protein;Gamma-IP10;IP-10;C7;Interferon-gamma induced protein CRG-2;Small-inducible cytokine B10;Cxcl10;Crg2, Ifi10, Inp10, Scyb10;

Protein Name :

C-X-C motif chemokine 10

Molecular Weight :

10789 MW

Protein Function :

In addition to its role as a proinflammatory cytokine, may participate in T-cell effector function and perhaps T-cell development.

Subcellular Localization :

Secreted.

Tissue Specificity :

Expressed in the spleen, thymus, lymph nodes and liver.

Background :

Chemokine (C-X-C motif) ligand 10 (CXCL10) or IP-10 is a small cytokine belonging to the CXC chemokine family that is also known as 10 kDa interferon-gamma-induced protein (gamma-IP10 or IP-10). CXCL10 is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis.It is a potent inhibitor of angiogenesis in vivo. The gene for CXCL10 is located on human chromosome 4 in a cluster among several other CXC chemokines. It is a RAS target gene and is overexpressed in the majority of colorectal cancers.This chemokine elicits its effects by binding to the cell surface chemokine receptor CXCR3.

Research Category :

Angiogenesis, Cancer, Chemokines, Immunology, Innate Immunity, Invasion/Microenvironment