Human CXCL4/PF4 ELISA Kit PicoKine® | Boster EK0726 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Boster

product type :

ELISA/assay

product name :

Human CXCL4/PF4 ELISA Kit PicoKine®

catalog :

EK0726

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0726

Product Name :

Human CXCL4/PF4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Human CXCL4/PF4 ELISA Kit PicoKine® (96 Tests). Quantitate Human PF4 in cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA). Sensitivity: 15pg/ml.

Reactivity :

Human

Application :

ELISA

Gene Name :

PF4

Uniprot ID :

P02776

Immunogen :

Expression system for standard: E.coli; Immunogen sequence: E32-S101

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

156 pg/ml - 10,000 pg/ml

Sensitivity :

<15 pg/ml

Sample Type :

cell culture supernatants, cell lysates, serum and plasma (heparin, EDTA)

Capture/Detection Antibodies :

a monoclonal antibody from mouse, a biotinylated polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Platelet factor 4

Synonyms :

Platelet factor 4;PF-4;C-X-C motif chemokine 4;Iroplact;Oncostatin-A;Platelet factor 4, short form;PF4;CXCL4, SCYB4;

Protein Name :

Platelet factor 4

Molecular Weight :

10845 MW

Protein Function :

Released during platelet aggregation. Neutralizes the anticoagulant effect of heparin because it binds more strongly to heparin than to the chondroitin-4-sulfate chains of the carrier molecule. Chemotactic for neutrophils and monocytes. Inhibits endothelial cell proliferation, the short form is a more potent inhibitor than the longer form.

Subcellular Localization :

Secreted.

Background :

Platelet factor 4 (PF4) is a small cytokine belonging to the CXC chemokine family that is also known as chemokine (C-X-C motif) ligand 4 (CXCL4). The PF4 gene was localized on 4q12-q13. Chemokines play fundamental roles in the development, homeostasis, and function of the immune system, and they have effects on cells of the central nervous system as well as on endothelial cells involved in angiogenesis or angiostasis. Platelet factor-4 is a 70-amino acid protein that is released from the alpha-granules of activated platelets and binds with high affinity to heparin. Its major physiologic role appears to be neutralization of heparin-like molecules on the endothelial surface of blood vessels, thereby inhibiting local antithrombin III activity and promoting coagulation. As a strong chemoattractant for neutrophils and fibroblasts, PF4 probably has a role in inflammation and wound repair.

Research Category :

Immunology, Atherosclerosis, Cardiovascular, Innate Immunity, Macrophage / Inflamm., Vascular Inflammation, Platelets, Chemokines