Mouse CTLA4 ELISA Kit PicoKine® | Boster EK0717 product information

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product summary

company name :

Boster

product type :

ELISA/assay

product name :

Mouse CTLA4 ELISA Kit PicoKine®

catalog :

EK0717

quantity :

96 wells/kit, with removable strips.

product information

SKU :

EK0717

Product Name :

Mouse CTLA4 ELISA Kit PicoKine®

Size :

96 wells/kit, with removable strips.

Description :

Mouse CTLA4 ELISA Kit PicoKine® (96 Tests). Quantitate Mouse Ctla4 in cell culture supernatants, serum and plasma (heparin). Sensitivity: 10 pg/ml.

Reactivity :

Mouse

Application :

ELISA

Gene Name :

CTLA4

Uniprot ID :

P09793

Immunogen :

Expression system for standard: NS0; Immunogen sequence: A37-F162

Cross-reactivity :

There is no detectable cross-reactivity with other relevant proteins.

Assay Range :

31.2 pg/ml - 2,000 pg/ml

Sensitivity :

<10 pg/ml

Sample Type :

cell culture supernatants, serum and plasma (heparin)

Capture/Detection Antibodies :

monoclonal antibody from rat, polyclonal antibody from goat

Storage :

Store at 4°C for 6 months, at -20°C for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Gene Full Name :

Cytotoxic T-lymphocyte protein 4

Synonyms :

Cytotoxic T-lymphocyte protein 4;Cytotoxic T-lymphocyte-associated antigen 4;CTLA-4;CD152;Ctla4;Cd152;

Protein Name :

Cytotoxic T-lymphocyte protein 4

Molecular Weight :

24993 MW

Protein Function :

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28 (By similarity).

Subcellular Localization :

Cell membrane ; Single-pass type I membrane protein .

Tissue Specificity :

Widely expressed with highest levels in lymphoid tissues.

Background :

CTLA-4 (Cytotoxic T-Lymphocyte Antigen 4), also known as CD152 (Cluster of differentiation 152), is a protein receptor that down regulates the immune system. CTLA4 is a member of the immunoglobulin superfamily, which is expressed on the surface of Helper T cells and transmits an inhibitory signal to T cells. CTLA4 is similar to the T-cell co-stimulatory protein, CD28, and both molecules bind to CD80 and CD86, also called B7-1 and B7-2 respectively, on antigen-presenting cells. CTLA4 transmits an inhibitory signal to T cells, whereas CD28 transmits a stimulatory signal. Blockade of CTLA4 expression in vitro augmented HIV-specific CD4-positive T-cell function.

Research Category :

Adaptive Immunity, Autoimmune, Hematopoietic Progenitors, Immune System Diseases, Immunology, Lymphoid, Non-Cd, Stem Cells, T Cells, T Lymphocytic Lineage